Joint Care And Repair
JOINT CARE AND REPAIR
360 Joint Care and Repair is a supplement made with high quality ingredients that helps reduce inflammation, boost your immune system and support joint and muscle health.
If you’re wondering how this might be, we can get into the nitty-gritty.
Each component of this supplement has unique properties.
They also have synergistic effects which helps compound the positive impact on your organism.
Turmeric, Ginger and their anti-inflammatory properties (1) (2) (3)
Turmeric contains a molecule called curcumin which is a potent inhibitor of the NF-κB pathway along with ginger.
This pathway is a DNA transcription factor that encourages expression of inflammatory molecules such as cytokines or enzymes involved in the production of eicosanoids. Other gene products can stimulate apoptosis which is a regulated form of cell death.
Curcumin and ginger have the ability to block the NF-κB and therefore prevent the downstream effects such as apoptosis, a heightened immune response as well as angiogenesis. The latter is a process that increases swelling because of increased blood flow by formation of new blood vessels.
Curcumin and ginger may also down regulate cytokines produced as a result of NF-κB stimulation. IL- 1, IL-6 and TNF-a have their activity reduced by curcumin. COX and LOX enzymes which provoke the release of prostaglandins from arachidonic acid located in the cell membrane, are also attenuated by curcumin and ginger.
The effects of the down regulation of these molecules benefit greatly conditions such as osteoarthritis and rheumatoid arthritis, resulting in healthy joints.
Curcumin, unfortunately, is not efficiently absorbed into the bloodstream.
For this reason we have BioPerine dosed at the right amount for optimal assimilation.
Glucosamine and Chondroitin for Joint Health (4)
Glucosamine and Chondroitin are both components of cartilage. Cushioning and articulation of the joint are heavily reliant upon the integrity of cartilage. If it is worn down to expose the bone and friction occurs, extreme pain and decreased mobility will be the result.
To avoid this we have to maintain the integrity of cartilage. Glucosamine has an anti-inflammatory effect but also stimulates anabolism by promoting osteoblast activity. Osteoblasts are the cells involved in connective tissue repair so adequate levels of stimulation are paramount in maintaining bone and cartilage health.
Chondroitin has similar effects being anti-inflammatory, anti-apoptotic, anti-catabolic and having anti-oxidant effects.
Another neat feature of glucosamine is its ability to bind to wheat lectins. Lectins are a type of protein that bond to sugar molecules; this can cause clumping of red blood cells and clotting.
Lectins can also harbor in joints and cause painful inflammation. Glucosamine can aid in mitigating this issue.
Methionine and MSM for the immune system and joint health (5) (6) (7)
Methionine is an essential amino acid; meaning it must be ingested because our bodies cannot produce it.
Once a cell is infected, it releases cytokines which are signaling molecules.
This causes migration of T cells that upon contact with the infected cell, begin to multiply. This process requires methionine as it crucial in protein synthesis and for methylation which allows for proper DNA transcription and therefore gene expression. Inadequate amounts of methionine will blunt an efficient immune response.
Methionine is a sulfur containing compound and that makes it important in cartilage formation. Sulfur deficiency increases risk of damage and slows down the healing process making one more susceptible to arthritis. Cartilage from healthy people has 3 times more sulfur than those that suffer from arthritis.
MSM has similar properties to methionine in the sense that it provides a large amount of sulfur for cartilage integrity. It has the ability to reduce joint degradation.
MSM is also potent in reducing inflammation and cytokine expression in a number of conditions. It can provoke death in cancer cells and restore cells to normal metabolism. MSM may have the additional capacity to accelerate wound closure.
Bromelain (8) (9)
Bromelain is a protease derived from pineapple. It breaks down proteins. You may have experienced its effect after eating pineapple with that tingling sensation it provides in the mouth.
This truly is a powerful enzyme because once it enters the bloodstream is can prevent blood clotting, destroy pathogens and relieve inflammation. It is even powerful in degrading the spike protein from a well known virus. Wound healing is vastly accelerated thanks to its features.
Bromelain also has a synergistic properties with curcumin; it enhances its absorption and ameliorates its anti-inflammatory effect.
Quercetin is a polyphenol derived from plants. It has a wide array of benefits that are anti-carcinogenic, anti-inflammatory, antiviral and it is an antioxidant.
It also has to function of preventing oxidation of fats in our cell membranes, reduces clotting and capillary permeability.
Quercetin has the particular capacity of binding to mast cells to prevent histamine release. Histamines are what cause allergic reactions.
Inflammatory markers such as CRP and GGT have been shown to be reduced with quercetin intake in humans. The bioavailability of it is optimized with this formula as it must be present with other bioflavonoids to enhance absorption.
Boswellia is a tree grown in India, North Africa and the Middle East. Throughout history it has been used in religious and cultural ceremonies. It provides an anti-inflammatory effect at the level of the joints. Boswellia is a much safer alternative to the commonly used NSAIDS used to deal with arthritic pain, as the side effects of the said drug are possible stomach bleeding and prevention of cartilage repair.
Boswellia specifically inhibits the 5-lipoxygenase enzyme involved in increasing the inflammatory response, calcium mobilization and free radical damage. Additionally, it drastically reduces cartilage degradation and helps maintain a healthier joint.
360 Joint Care and Repair contains the right high quality ingredients for better joints, immune support and recovery. Each component has a specific function, whereas together they have a compounding synergistic effect to boost the functioning of your cells and maintain homeostasis.
A system doesn’t work correctly without the proper tools. If we do not provide those tools our organisms need, it will suffer. Its resources are not infinite, we must ingest the right ingredients to avoid malfunctioning.
- Alan Deely